A comparison among stochastic optimization algorithms for parameter estimation of biochemical kinetic models

Mathematical models in biochemical engineering field are usually composed by nonlinear kinetic equations, where the number of parameters that must be estimated from a set of experimental measurements is usually very high. In these cases, the estimation of the model parameters comprises numerical iterative methods for minimization of the objective function. Classical methods for minimization of the objective function, like the Newton method, requires a good initial guess for all parameters and differentiation of the objective function and/or model equations with respect to the model parameters. Besides, the use lobal optimization ifferential Evolution article swarm arameter estimation ioreactors of stochastic optimization methods for parameter estimation has gained attention, since these methods do not require a good initial guesses of all model parameters and neither the evaluation of derivatives. In this work, some stochastic optimization methods (Artificial Bee Colony, Differential Evolution, Particle Swarm Optimization and Simulated Annealing) were used in the estimation of kinetic parameters of a biochemical model for an alcoholic fermentation of cassava hydrolyzed. The results indicated that vides Differential Evolution pro